CLINICAL TRIALS AND OBSERVATIONS Minimally differentiated acute myeloid leukemia (FAB AML-M0) is associated with an adverse outcome in children: a report from the Children’s Oncology Group, studies CCG-2891 and CCG-2961
نویسندگان
چکیده
1Division of Hematology/Oncology/BMT, BC’s Children’s Hospital, Vancouver, BC, Canada; 2Department of Preventive Medicine, University of Southern California, Los Angeles; 3Children’s Oncology Group, Arcadia, CA; 4Fred Hutchinson Cancer Research Center, Seattle, WA; 5Department of Pathology, Ohio State University, Columbus; 6Division of Pediatric Hematology/Oncology, IWK Health Center, Halifax, NS, Canada; 7Pediatric Oncology, Children’s Hospital of Philadelphia, PA; 8AFLAC Cancer Center and Blood Disorders Service, Children’s Healthcare of Atlanta, GA; 9Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; 10Division of Hematology/Oncology, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, OH
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children’s Oncology Group
We evaluated differences in outcome by ethnicity among children with acute myeloid leukemia (AML). We analyzed 791 children in the CCG 2891 trial and confirmed positive findings in 850 children in the CCG 2961 trial. Hispanic and black children treated with chemotherapy in CCG 2891 had significantly inferior overall survival (OS) from study entry compared with white children (37% 9% vs 48% 4% [...
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1University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, Division of Oncology, Philadelphia; 2Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, OH; 3Children’s Hospital of Oakland, CA; 4Izaak W. Killam Hospital for Children, Halifax, NS; 5Food and Drug Administration, Silver Spring, MD; 6University of Californi...
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Activating mutations of the FLT3 gene occur because of an internal tandem duplication of the juxta-membrane domain (FLT3/ITD) or point mutation of the activation loop domain (FLT3/ALM). The presence of FLT3 mutations as well as the allelic ratio of FLT3/ITD (ITD-AR, mutant– wild type ratio) may have prognostic significance. FLT3 mutation status of 630 children with de novo acute myeloid leukemi...
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1Division of Hematology-Oncology, Doernbecher Children’s Hospital/Oregon Health & Science University, Portland; 2Division of Hematology-Oncology, Rainbow Babies & Children’s Hospital, Case Western Reserve University, Cleveland, OH; 3Division of Hematology-Oncology, The Children’s Medical Center/Wright State University Boonshoft School of Medicine, Dayton, OH; 4Children’s Oncology Group, Statist...
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We assessed the outcome of children with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) receiving contemporary risk-based therapy by evaluating clinical and biologic features and outcome of children with ALL, with or without DS, enrolled in Children’s Cancer Group (CCG) protocols between 1983 and 1995. Comparison of characteristics of children with ALL with (ALL-DS; n 179) or without...
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